El-Agnaf, Omar M.A.: search on Z-Library

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1

mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish

Owen A. Ross, Rose McCormack, Lynn D. Maxwell, R.Alistair Duguid, Derek J. Quinn, Yvonne A. Barnett, I.Maeve Rea, Omar M.A. El-Agnaf, J.Mark Gibson, Andrew Wallace, Derek Middleton, Martin D. Curran

Journal:

Experimental Gerontology

Year:

2003

Language:

english

File:

PDF, 134 KB

english, 2003

2

Quantification of brain-derived extracellular vesicles in plasma as a biomarker to diagnose Parkinson's and related diseases

Ohmichi, Takuma, Mitsuhashi, Masato, Tatebe, Harutsugu, Kasai, Takashi, Ali El-Agnaf, Omar M., Tokuda, Takahiko

Journal:

Parkinsonism & Related Disorders

Year:

2018

Language:

english

File:

PDF, 602 KB

english, 2018

3

Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease

Spencer, Brian, Trinh, Ivy, Rockenstein, Edward, Mante, Michael, Florio, Jazmin, Adame, Anthony, El-Agnaf, Omar M.A., Kim, Changyoun, Masliah, Eliezer, Rissman, Robert A.

Journal:

Neurobiology of Disease

Year:

2019

File:

PDF, 8.57 MB

2019

4

Glycation in Parkinson's disease and Alzheimer's disease

Vicente Miranda, Hugo, El-Agnaf, Omar M. A., Outeiro, Tiago Fleming

Journal:

Movement Disorders

Year:

2016

Language:

english

File:

PDF, 512 KB

english, 2016

5

Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease

Spencer, Brian, Trinh, Ivy, Rockenstein, Edward, Mante, Michael, Florio, Jazmin, Adame, Anthony, El-Agnaf, Omar M.A., Kim, Changyoun, Masliah, Eliezer, Rissman, Robert A.

Journal:

Neurobiology of Disease

Year:

2019

Language:

english

File:

PDF, 8.57 MB

english, 2019

6

Oligomerisation and toxicity of alpha-synuclein

El-Agnaf, Omar M. A.

Journal:

Biochemical Society Transactions

Year:

2002

Language:

english

File:

PDF, 110 KB

english, 2002

7

The synthesis of some peptides related to the amyloid β peptide 25–35: Use ofN-(2-hydroxy-4-methoxybenzyl) protection

Omar M. A. El-Agnaf, Patrick Harriott, David J. S. Guthrie, G. Brent Irvine, Brian Walker

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1994

Language:

english

File:

PDF, 414 KB

english, 1994

8

Development of Non-Viral Vectors Targeting the Brain as a Therapy for Parkinson’S Disease and Other Brain Disorders

Javed, Hayate, Menon, Sindhu A., Al-Mansoori, Karima M., Al-Wandi, Mojib, Majbour, Nour K., Ardah, Mustafa T., Varghese, Shiji, Vaikath, Nishant N., Haque, M Emdadul, Azzouz, Mimoun, El-Agnaf, Omar M.

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 1.56 MB

english, 2015

9

Mutation screening in exons 3 and 4 of α-synuclein in sporadic Parkinsonʼs and sporadic and familial dementia with Lewy bodies cases

El-Agnaf, Omar M. A., Curran, Martin D., Wallace, Andrew, Middleton, Derek, Murgatroyd, Christopher, Curtis, Anne, Perry, Robert, Jaros, Evelyn

Journal:

Year:

1998

Language:

english

File:

PDF, 693 KB

english, 1998

10

New evidence that the Alzheimer β-amyloid peptide does not spontaneously form free radicals: An ESR study using a series of spin-traps

Stuart Turnbull, Brian J Tabner, Omar M.A El-Agnaf, Lance J Twyman, David Allsop

Journal:

Free Radical Biology and Medicine

Year:

2001

Language:

english

File:

PDF, 268 KB

english, 2001

11

Non-fibrillar oligomeric species of the amyloid ABri peptide, implicated in familial British dementia, are more potent at inducing apoptotic cell death than protofibrils or mature fibrils

Omar M.A El-Agnaf, Sidhartha Nagala, Bhroma P Patel, Brian M Austen

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 677 KB

english, 2001

12

Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease

Takahiko Tokuda, Sultan A. Salem, David Allsop, Toshiki Mizuno, Masanori Nakagawa, Mohamed M. Qureshi, Joseph J. Locascio, Michael G. Schlossmacher, Omar M.A. El-Agnaf

Journal:

Biochemical and Biophysical Research Communications

Year:

2006

Language:

english

File:

PDF, 291 KB

english, 2006

13

O2-06-03 A strategy for designing inhibitors of α-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders

Omar M. El-Agnaf, Katerina E. Paleologou, David Allsop

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 161 KB

english, 2004

14

Conformation and toxicity of the ABRI peptide in familial British dementia

Omar Ma El-Agnaf, Guiliano Siligardi, Joseph M. Sheridan, Brian M. Austen

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 180 KB

english, 2000

15

Assemblies of Alzheimer’s peptides Aβ25–35 and Aβ31–35: reverse-turn conformation and side-chain interactions revealed by X-ray diffraction

Jeremy P. Bond, Sean P. Deverin, Hideyo Inouye, Omar M.A. El-Agnaf, Martha M. Teeter, Daniel A. Kirschner

Journal:

Journal of Structural Biology

Year:

2003

Language:

english

File:

PDF, 915 KB

english, 2003

16

Cerebrospinal fluid biomarkers in Parkinson disease

Parnetti, Lucilla, Castrioto, Anna, Chiasserini, Davide, Persichetti, Emanuele, Tambasco, Nicola, El-Agnaf, Omar, Calabresi, Paolo

Journal:

Nature Reviews Neurology (formerly Nature Clinical Practice Neurology)

Year:

2013

Language:

english

File:

PDF, 290 KB

english, 2013

17

Targeting α-synuclein as a therapeutic strategy for Parkinson’s disease

Lawand, Nada B, Saadé, Nayef E, El-Agnaf, Omar M, Safieh-Garabedian, Bared

Journal:

Expert Opinion on Therapeutic Targets

Year:

2015

Language:

english

File:

PDF, 297 KB

english, 2015

18

A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein

Landeck, Natalie, Hall, Hélène, Ardah, Mustafa T., Majbour, Nour K., El-Agnaf, Omar M. A., Halliday, Glenda, Kirik, Deniz

Journal:

Molecular Neurodegeneration

Year:

2016

Language:

english

File:

PDF, 2.99 MB

english, 2016

19

Studies on peptides containing the 25–35 sequence of amyloid β peptide

EL-AGNAF, OMAR A., GUTHRIE, DAVID J.S., IRVINE, G. BRENT

Journal:

Biochemical Society Transactions

Year:

1995

Language:

english

File:

PDF, 142 KB

english, 1995

20

Production of Reactive Oxygen Species from Aggregating Proteins Implicated in Alzheimers Disease, Parkinsons Disease and Other Neurodegenerative Diseases

Brian J. Tabner, Bentham Science Publisher, Stuart Turnbull, Bentham Science Publisher, Omar M.A. El-Agnaf, Bentham Science Publisher, David Allsop, Bentham Science Publisher

Journal:

Current Topics in Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 155 KB

english, 2001

21

Tissue-Specific Delivery of CRISPR Therapeutics: Strategies and Mechanisms of Non-Viral Vectors

Shalaby, Karim, Aouida, Mustapha, El-Agnaf, Omar

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 2.03 MB

2020

22

CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinsonâ²s Disease

Oosterveld, Linda P., Kuiper, Tessa I., Majbour, Nour K., Verberk, Inge M. W., van Dijk, Karin D., Twisk, Jos W. R., El-Agnaf, Omar M., Teunissen, Charlotte E., Weinstein, Henry C., Klein, Martin, Ber

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 1.00 MB

2020

23

α-synuclein implicated in Parkinson’s disease catalyses the formation of hydrogen peroxide in vitro

Stuart Turnbull, Brian J Tabner, Omar M.A El-Agnaf, Susan Moore, Yvonne Davies, David Allsop

Journal:

Free Radical Biology and Medicine

Year:

2001

Language:

english

File:

PDF, 373 KB

english, 2001

24

Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments

Omar M.A El-Agnaf, Ross Jakes, Martin D Curran, Derek Middleton, Raffaele Ingenito, Elisabetta Bianchi, Antonello Pessi, David Neill, Andrew Wallace

Journal:

Year:

1998

Language:

english

File:

PDF, 206 KB

english, 1998

25

The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro

Dulovic, Marija, Jovanovic, Maja, Xilouri, Maria, Stefanis, Leonidas, Harhaji-Trajkovic, Ljubica, Kravic-Stevovic, Tamara, Paunovic, Verica, Ardah, Mustafa T., El-Agnaf, Omar M.A., Kostic, Vladimir, M

Journal:

Neurobiology of Disease

Year:

2014

Language:

english

File:

PDF, 3.40 MB

english, 2014

26

Early-onset parkinsonism in a pedigree with phosphoglycerate kinase deficiency and a heterozygous carrier: do PGK-1 mutations contribute to vulnerability to parkinsonism?

Sakaue, Satoshi, Kasai, Takashi, Mizuta, Ikuko, Suematsu, Masaya, Osone, Shinya, Azuma, Yumiko, Imamura, Toshihiko, Tokuda, Takahiko, Kanno, Hitoshi, El-Agnaf, Omar M. A., Morimoto, Masafumi, Nakagawa

Journal:

npj Parkinson s Disease

Year:

2017

Language:

english

File:

PDF, 761 KB

english, 2017

27

Fe(II)-induced DNA damage in α-synuclein-transfected human dopaminergic BE(2)-M17 neuroblastoma cells: detection by the Comet assay

Francis L. Martin, Sally J. M. Williamson, Katerina E. Paleologou, Rebecca Hewitt, Omar M. A. El-Agnaf, David Allsop

Journal:

Journal of Neurochemistry

Year:

2003

Language:

english

File:

PDF, 293 KB

english, 2003

28

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of α-synuclein protein implicated in Parkinson's disease

Omar M.A El-Agnaf, Ross Jakes, Martin D Curran, Andrew Wallace

Journal:

Year:

1998

Language:

english

File:

PDF, 264 KB

english, 1998

29

Oligomerization of β-amyloid of the Alzheimer’s and the Dutch-cerebral-haemorrhage types

SIAN, Aneet K., FREARS, Emma R., EL-AGNAF, Omar M. A., PATEL, Bhroma P., MANCA, Maria F., SILIGARDI, Giuliano, HUSSAIN, Rohanah, AUSTEN, Brian M.

Journal:

Biochemical Journal

Year:

2000

Language:

english

File:

PDF, 588 KB

english, 2000

30

Cognitive impairment in Parkinson's disease

Majbour, Nour, El-Agnaf, Omar

Journal:

The Lancet Neurology

Year:

2016

Language:

english

File:

PDF, 88 KB

english, 2016

31

Soluble oligomers for the diagnosis of neurodegenerative diseases

Omar MA El-Agnaf, Dominic M Walsh, David Allsop

Journal:

The Lancet Neurology

Year:

2003

Language:

english

File:

PDF, 170 KB

english, 2003

32

Increased α-synuclein levels in the cerebrospinal fluid of patients with Creutzfeldt–Jakob disease

Kasai, Takashi, Tokuda, Takahiko, Ishii, Ryotaro, Ishigami, Noriko, Tsuboi, Yoshio, Nakagawa, Masanori, Mizuno, Toshiki, El-Agnaf, Omar M. A.

Journal:

Journal of Neurology

Year:

2014

Language:

english

File:

PDF, 243 KB

english, 2014

33

Comparative studies on peptides representing the so-called tachykinin-like region of the Alzheimer Aβ peptide [Aβ(25–35)]

EL-AGNAF, Omar M. A., IRVINE, G. Brent, FITZPATRICK, Geraldine, GLASS, W. Kenneth, GUTHRIE, David J. S.

Journal:

Biochemical Journal

Year:

1998

Language:

english

File:

PDF, 223 KB

english, 1998

34

Aggregation and properties of α‒synuclein and related proteins

El-Agnaf, Omar M. A., Irvine, G. Brent

Journal:

Spectroscopy / An International Journal

Year:

2001

Language:

english

File:

PDF, 1.27 MB

english, 2001

35

Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy

El-Agnaf, Omar, Overk, Cassia, Rockenstein, Edward, Mante, Michael, Florio, Jazmin, Adame, Anthony, Vaikath, Nishant, Majbour, Nour, Lee, Seung-Jae, Kim, Changyoun, Masliah, Eliezer, Rissman, Robert A

Journal:

Neurobiology of Disease

Year:

2017

Language:

english

File:

PDF, 3.42 MB

english, 2017

36

O3-04-05 A possible role for the formation of hydrogen peroxide during the early stages of protein aggregation in the pathogenesis of Alzheimer's disease and other neurodegenerative disorders

Stuart Turnbull, Brian J. Tabner, Omar El-Agnaf, Fiona Benson, Jennifer King, Lee Hayes, David Allsop

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 164 KB

english, 2004

37

A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on β-amyloid and α-synuclein

Tabner, Brian J., Turnbull, Stuart, King, Jenny E., Benson, Fiona E., El-Agnaf, Omar M.A., Allsop, David

Journal:

Free Radical Research

Year:

2006

Language:

english

File:

PDF, 229 KB

english, 2006

38

Validation of electrochemiluminescence assays for highly sensitive and reproducible quantification of α-synuclein in cerebrospinal fluid

Kruse, Niels, El-Agnaf, Omar M, Mollenhauer, Brit

Journal:

Year:

2017

Language:

english

File:

PDF, 1.45 MB

english, 2017

39

Safety and immunogenicity of the Î±-synuclein active immunotherapeutic PD01A in patients with Parkinson's disease: a randomised, single-blinded, phase 1 trial

Volc, Dieter, Poewe, Werner, Kutzelnigg, Alexandra, LÃ¼hrs, Petra, Thun-Hohenstein, Caroline, Schneeberger, Achim, Galabova, Gergana, Majbour, Nour, Vaikath, Nishant, El-Agnaf, Omar, Winter, Dorian, M

Journal:

The Lancet Neurology

Year:

2020

File:

PDF, 1.55 MB

2020

40

Fluorescence Anisotropy: A Method for Early Detection of Alzheimer β-Peptide (Aβ) Aggregation

David Allsop, Linda Swanson, Susan Moore, Yvonne Davies, Amber York, Omar M.A. El-Agnaf, Ian Soutar

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 2.75 MB

english, 2001

41

HARMONIZATION OF IMMUNOCHEMICAL METHODS FOR MEASUREMENT OF α-SYNUCLEIN IN HUMAN CEREBROSPINAL FLUID: A ROUND ROBIN STUDY APPROACH

Hutten, Samantha J., Mollenhauer, Brit, Bowman, F Dubois, Drake, Daniel, Duong, Jimmy, Blennow, Kaj, Corradini, Veronika, El-Agnaf, Omar M.A., Shaw, Leslie M., Masucci, Jennifer, Taylor, Peggy, Umek,

Journal:

Alzheimer's & Dementia

Year:

2018

Language:

english

File:

PDF, 80 KB

english, 2018

42

Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls

Erskine, Daniel, Reeve, Amy K., Polvikoski, Tuomo, Schaefer, Andrew M., Taylor, Robert W., Lax, Nichola Z., El-Agnaf, Omar, Attems, Johannes, Gorman, Gráinne S., Turnbull, Doug M., Ng, Yi Shau

Journal:

Acta Neuropathologica

Year:

2019

Language:

english

File:

PDF, 735 KB

english, 2019

43

Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies

Hatton, Christopher, Reeve, Amy, Lax, Nichola Zoe, Blain, Alasdair, Ng, Yi Shiau, El-Agnaf, Omar, Attems, Johannes, Taylor, John-Paul, Turnbull, Doug, Erskine, Daniel

Journal:

Acta Neuropathologica Communications

Year:

2020

File:

PDF, 5.14 MB

2020

44

CSF α-synuclein levels in dementia with Lewy bodies and Alzheimer's disease

Moeko Noguchi-Shinohara, Takahiko Tokuda, Mitsuhiro Yoshita, Takashi Kasai, Kenjiro Ono, Masanori Nakagawa, Omar M.A. El-Agnaf, Masahito Yamada

Journal:

Year:

2009

Language:

english

File:

PDF, 332 KB

english, 2009

45

Copper-mediated formation of hydrogen peroxide from the amylin peptide: A novel mechanism for degeneration of islet cells in type-2 diabetes mellitus?

Atef Masad, Lee Hayes, Brian J. Tabner, Stuart Turnbull, Leanne J. Cooper, Nigel J. Fullwood, Matthew J. German, Fuyuki Kametani, Omar M.A. El-Agnaf, David Allsop

Journal:

Year:

2007

Language:

english

File:

PDF, 513 KB

english, 2007

46

Properties of some peptides related to amyloid β-peptide

El-Agnaf, Omar M. A., Irvine, G. Brent, Guthrie, David J. S., Walsh, Dominic M.

Journal:

Biochemical Society Transactions

Year:

1996

Language:

english

File:

PDF, 117 KB

english, 1996

47

Quantification of CSF and blood alpha-synuclein as a diagnostic marker for synucleinopathies

Brit Mollenhauer, Otte Birgit, Juliana Ng, Omar El-Agnaf, Clemens Scherzer, Claudia Trenkwalde

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 100 KB

english, 2009

48

Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer’s disease and Parkinson’s disease

Brian J. Tabner, Stuart Turnbull, Omar M.A. El-Agnaf, David Allsop

Journal:

Free Radical Biology and Medicine

Year:

2002

Language:

english

File:

PDF, 124 KB

english, 2002

49

Conformation and toxicity of the fibrillogenic ABri peptide in familial British dementia

El-Agnaf, Omar M. A., Sheridan, Joe. M., Siligardi, Giuliano, Austen, Brian. M.

Journal:

Biochemical Society Transactions

Year:

2000

Language:

english

File:

PDF, 141 KB

english, 2000

50

Successful syntheses of β amyloid-(25–35)-peptide: a difficult sequence by N -(9-fluorenylmethoxycarbonyl) chemistry

Guthrie, David J. S., El-Agnaf, Omar, Harriott, Patrick, Irvine, G. Brent, Walker, Brian

Journal:

Biochemical Society Transactions

Year:

1994

Language:

english

File:

PDF, 285 KB

english, 1994

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